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Are organizing circuits, equipment to be checked. Chinese scientists discover new mechanism solvable targeted cancer therapy drug, according to the Xinhua News Agency on when people have high hopes of molecular targeted therapy, it appears a disappointing problem: drug resistance. Why is this so? A recent study by Chinese scientists found another tumor promotion channel carcinogenic targets, reveals a new mechanism of resistance to targeted therapy, which is targeted to develop new ideas for drug development. The study, recently published in the international science magazine Nature 'Nature Communications', the chief scientist of the Ministry of Science major research program, led by the Yangtze River scholar Professor Liu Qiang, Zhongshan University and Dalian Medical University, Ministry of Education, 'innovation team' for the main study, coordinated United Kingdom Imperial College London, the United States Anderson cancer Center and other famous research institutions to complete. Molecular targeted therapy to carcinogenic effects due to precise site is known as the 'biological missiles.' Said Liu Qiang, tumor biology have identified a variety of protein kinases abnormal expression in malignant tumors, these kinases become a therapeutic target. Currently, these targets have been developed for a variety of targeted drugs, such as Gleevec, Iressa and so on. These drugs primarily through inhibition of the kinase activity of the target protein to play its role in cancer. Targeted drug therapy has been successfully used clinically, however, there are still many patients are not sensitive to treatment, drug resistance, leading to treatment failure. 'Biological missile' Why the face of some tumors become 'dud'? Said Liu Qiang, which stems from our understanding of the 'enemy' is not enough. Liu Qiang led the team on cancer-promoting mechanism of the target protein kinase-dependent in the study found. They breast cancer as a model, found to have abnormal cellular localization of one kind of aurora kinase protein in tumors, increases the biological characteristics of the target protein kinase, resulting in non-dependent kinase activity of cancer-promoting function, can be used as nuclear transcription factor promotes breast cancer stem cells self-renewal, make it kinase inhibitor (targeted drug) to produce resistance, leading to drug resistance. By correcting abnormal cellular localization of the target kinase, inhibits its nuclear capabilities, it is possible to overcome the resistance. Blasting firecrackers less busy promotional year found that in case of contamination weather conscious people